Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Col1a1  collagen, type I, alpha 1   (Synonyms: Col1a-1, Cola1, Cola-1, Mov-13)
Results	Reference
1	J:87161 Aberg T, Cavender A, Gaikwad JS, Bronckers AL, Wang X, Waltimo-Siren J, Thesleff I, D'Souza RN, Phenotypic changes in dentition of Runx2 homozygote-null mutant mice. J Histochem Cytochem. 2004 Jan;52(1):131-9
1	J:185552 Acharya A, Baek ST, Huang G, Eskiocak B, Goetsch S, Sung CY, Banfi S, Sauer MF, Olsen GS, Duffield JS, Olson EN, Tallquist MD, The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors. Development. 2012 Jun;139(12):2139-49
1	J:166547 Airik R, Trowe MO, Foik A, Farin HF, Petry M, Schuster-Gossler K, Schweizer M, Scherer G, Kist R, Kispert A, Hydroureternephrosis due to loss of Sox9-regulated smooth muscle cell differentiation of the ureteric mesenchyme. Hum Mol Genet. 2010 Dec 15;19(24):4918-29
1	J:310588 Amara CS, Fabritius C, Houben A, Wolff LI, Hartmann C, CaMKII Signaling Stimulates Mef2c Activity In Vitro but Only Minimally Affects Murine Long Bone Development in vivo. Front Cell Dev Biol. 2017;5:20
1	J:67299 Arikawa-Hirasawa E, Watanabe H, Takami H, Hassell JR, Yamada Y, Perlecan is essential for cartilage and cephalic development. Nat Genet. 1999 Nov;23(3):354-8
1*	J:272619 Aydogdu N, Rudat C, Trowe MO, Kaiser M, Ludtke TH, Taketo MM, Christoffels VM, Moon A, Kispert A, TBX2 and TBX3 act downstream of canonical WNT signaling in patterning and differentiation of the mouse ureteric mesenchyme. Development. 2018 Nov 26;145(23):dev171827
1*	J:56413 Bachner D, Ahrens M, Betat N, Schroder D, Gross G, Developmental expression analysis of murine autotaxin (ATX). Mech Dev. 1999 Jun;84(1-2):121-5
1	J:47096 Bidder M, Latifi T, Towler DA, Reciprocal temporospatial patterns of Msx2 and Osteocalcin gene expression during murine odontogenesis. J Bone Miner Res. 1998 Apr;13(4):609-19
1	J:186553 Braitsch CM, Combs MD, Quaggin SE, Yutzey KE, Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium-derived cells into smooth muscle in the developing heart. Dev Biol. 2012 Aug 15;368(2):345-57
1	J:183485 Chen D, Jarrell A, Guo C, Lang R, Atit R, Dermal beta-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation. Development. 2012 Apr;139(8):1522-33
1	J:97179 Colnot C, de la Fuente L, Huang S, Hu D, Lu C, St-Jacques B, Helms JA, Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development. Development. 2005 Mar;132(5):1057-67
1	J:128902 de Frutos CA, Vega S, Manzanares M, Flores JM, Huertas H, Martinez-Frias ML, Nieto MA, Snail1 is a transcriptional effector of FGFR3 signaling during chondrogenesis and achondroplasias. Dev Cell. 2007 Dec;13(6):872-83
1	J:295760 Felsenthal N, Rubin S, Stern T, Krief S, Pal D, Pryce BA, Schweitzer R, Zelzer E, Development of migrating tendon-bone attachments involves replacement of progenitor populations. Development. 2018 Dec 18;145(24):dev165381
1	J:98430 Glass DA 2nd, Bialek P, Ahn JD, Starbuck M, Patel MS, Clevers H, Taketo MM, Long F, McMahon AP, Lang RA, Karsenty G, Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell. 2005 May;8(5):751-64
1	J:336727 Gorrell L, Makareeva E, Omari S, Otsuru S, Leikin S, ER, Mitochondria, and ISR Regulation by mt-HSP70 and ATF5 upon Procollagen Misfolding in Osteoblasts. Adv Sci (Weinh). 2022 Oct;9(29):e2201273
1	J:131986 Han M, Yang X, Lee J, Allan CH, Muneoka K, Development and regeneration of the neonatal digit tip in mice. Dev Biol. 2008 Mar 1;315(1):125-35
1	J:98426 Hill TP, Spater D, Taketo MM, Birchmeier W, Hartmann C, Canonical Wnt/beta-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes. Dev Cell. 2005 May;8(5):727-38
1*	J:233142 Hilton MJ, Tu X, Wu X, Bai S, Zhao H, Kobayashi T, Kronenberg HM, Teitelbaum SL, Ross FP, Kopan R, Long F, Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med. 2008 Mar;14(3):306-14
1	J:94274 Hu H, Hilton MJ, Tu X, Yu K, Ornitz DM, Long F, Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development. 2005 Jan;132(1):49-60
1	J:122952 Hung IH, Yu K, Lavine KJ, Ornitz DM, FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod. Dev Biol. 2007 Jul 15;307(2):300-13
1*	J:54095 Inada M, Yasui T, Nomura S, Miyake S, Deguchi K, Himeno M, Sato M, Yamagiwa H, Kimura T, Yasui N, Ochi T, Endo N, Kitamura Y, Kishimoto T, Komori T, Maturational disturbance of chondrocytes in Cbfa1-deficient mice. Dev Dyn. 1999 Apr;214(4):279-90
1*	J:300574 Jiang Q, Qin X, Yoshida CA, Komori H, Yamana K, Ohba S, Hojo H, Croix BS, Kawata-Matsuura VKS, Komori T, Antxr1, Which is a Target of Runx2, Regulates Chondrocyte Proliferation and Apoptosis. Int J Mol Sci. 2020 Mar 31;21(7):2425
1	J:298035 Kelly NH, Huynh NPT, Guilak F, Single cell RNA-sequencing reveals cellular heterogeneity and trajectories of lineage specification during murine embryonic limb development. Matrix Biol. 2020 Jul;89:1-10
1	J:104946 Kieslinger M, Folberth S, Dobreva G, Dorn T, Croci L, Erben R, Consalez GG, Grosschedl R, EBF2 regulates osteoblast-dependent differentiation of osteoclasts. Dev Cell. 2005 Dec;9(6):757-67
1	J:182744 Kohn A, Dong Y, Mirando AJ, Jesse AM, Honjo T, Zuscik MJ, O'Keefe RJ, Hilton MJ, Cartilage-specific RBPjkappa-dependent and -independent Notch signals regulate cartilage and bone development. Development. 2012 Mar;139(6):1198-212
1	J:72784 Kovacs CS, Chafe LL, Fudge NJ, Friel JK, Manley NR, Pth regulates fetal blood calcium and skeletal mineralization independently of pthrp. Endocrinology. 2001 Nov;142(11):4983-93
1	J:99514 Kovacs CS, Woodland ML, Fudge NJ, Friel JK, The vitamin D receptor is not required for fetal mineral homeostasis or for the regulation of placental calcium transfer in mice. Am J Physiol Endocrinol Metab. 2005 Jul;289(1):E133-44
1	J:308781 Lejard V, Blais F, Guerquin MJ, Bonnet A, Bonnin MA, Havis E, Malbouyres M, Bidaud CB, Maro G, Gilardi-Hebenstreit P, Rossert J, Ruggiero F, Duprez D, EGR1 and EGR2 involvement in vertebrate tendon differentiation. J Biol Chem. 2011 Feb 18;286(7):5855-67
1	J:193842 Lu C, Wan Y, Cao J, Zhu X, Yu J, Zhou R, Yao Y, Zhang L, Zhao H, Li H, Zhao J, He L, Ma G, Yang X, Yao Z, Guo X, Wnt-mediated reciprocal regulation between cartilage and bone development during endochondral ossification. Bone. 2013 Apr;53(2):566-74
1	J:296737 Matsuura VKSK, Yoshida CA, Komori H, Sakane C, Yamana K, Jiang Q, Komori T, Expression of a Constitutively Active Form of Hck in Chondrocytes Activates Wnt and Hedgehog Signaling Pathways, and Induces Chondrocyte Proliferation in Mice. Int J Mol Sci. 2020 Apr 12;21(8):2682
1	J:95408 McDonald KR, Fudge NJ, Woodrow JP, Friel JK, Hoff AO, Gagel RF, Kovacs CS, Ablation of calcitonin/calcitonin gene-related peptide-alpha impairs fetal magnesium but not calcium homeostasis. Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E218-26
1	J:151888 Mead TJ, Yutzey KE, Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14420-5
1*	J:186526 Michikami I, Fukushi T, Honma S, Yoshioka S, Itoh S, Muragaki Y, Kurisu K, Ooshima T, Wakisaka S, Abe M, Trps1 is necessary for normal temporomandibular joint development. Cell Tissue Res. 2012 Apr;348(1):131-40
1	J:182340 Michikami I, Fukushi T, Tanaka M, Egusa H, Maeda Y, Ooshima T, Wakisaka S, Abe M, Kruppel-like factor 4 regulates membranous and endochondral ossification. Exp Cell Res. 2012 Feb 15;318(4):311-25
1	J:170582 Mundy C, Yasuda T, Kinumatsu T, Yamaguchi Y, Iwamoto M, Enomoto-Iwamoto M, Koyama E, Pacifici M, Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spine. Dev Biol. 2011 Mar 1;351(1):70-81
1*	J:74179 Nikaido T, Yokoya S, Mori T, Hagino S, Iseki K, Zhang Y, Takeuchi M, Takaki H, Kikuchi S, Wanaka A, Expression of the novel transcription factor OASIS, which belongs to the CREB/ATF family, in mouse embryo with special reference to bone development. Histochem Cell Biol. 2001 Aug;116(2):141-8
1	J:230306 Odelin G, Faure E, Kober F, Maurel-Zaffran C, Theron A, Coulpier F, Guillet B, Bernard M, Avierinos JF, Charnay P, Topilko P, Zaffran S, Loss of Krox20 results in aortic valve regurgitation and impaired transcriptional activation of fibrillar collagen genes. Cardiovasc Res. 2014 Dec 1;104(3):443-55
1*	J:121723 Oka S, Oka K, Xu X, Sasaki T, Bringas P Jr, Chai Y, Cell autonomous requirement for TGF-beta signaling during odontoblast differentiation and dentin matrix formation. Mech Dev. 2007 Jul;124(6):409-15
1*	J:116229 Roulet M, Ruggiero F, Karsenty G, Leguellec D, A comprehensive study of the spatial and temporal expression of the col5a1 gene in mouse embryos: a clue for understanding collagen V function in developing connective tissues. Cell Tissue Res. 2007 Feb;327(2):323-32
1	J:44842 Savontaus M, Metsaranta M, Vuorio E, Mutation in type II collagen gene disturbs spinal development and gene expression patterns in transgenic Del1 mice. Lab Invest. 1997 Dec;77(6):591-600
1*	J:37148 Savontaus M, Metsranta M, Vuorio E, Retarded skeletal development in transgenic mice with a type II collagen mutation. Am J Pathol. 1996 Dec;149(6):2169-82
1	J:88710 Shin HI, Divieti P, Sims NA, Kobayashi T, Miao D, Karaplis AC, Baron R, Bringhurst R, Kronenberg HM, Gp130-mediated signaling is necessary for normal osteoblastic function in vivo and in vitro. Endocrinology. 2004 Mar;145(3):1376-85
1*	J:262633 Shukunami C, Takimoto A, Nishizaki Y, Yoshimoto Y, Tanaka S, Miura S, Watanabe H, Sakuma T, Yamamoto T, Kondoh G, Hiraki Y, Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes. Sci Rep. 2018 Feb 16;8(1):3155
1	J:187998 Shung CY, Ota S, Zhou ZQ, Keene DR, Hurlin PJ, Disruption of a Sox9-beta-catenin circuit by mutant Fgfr3 in thanatophoric dysplasia type II. Hum Mol Genet. 2012 Nov 1;21(21):4628-44
1	J:185693 Smith CL, Baek ST, Sung CY, Tallquist MD, Epicardial-derived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling. Circ Res. 2011 Jun 10;108(12):e15-26
1*	J:36919 Tanaka Y, Kobayashi K, Kita M, Masuda H, Kinoshita S, Nagata K, Imanishi J, Expression of 47 kDa heat shock protein (HSP47) during development of mouse cornea. Exp Eye Res. 1996 Oct;63(4):383-93
1*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1*	J:67747 Thut CJ, Rountree RB, Hwa M, Kingsley DM, A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens. Dev Biol. 2001 Mar 1;231(1):63-76
1	J:94631 Vega RB, Matsuda K, Oh J, Barbosa AC, Yang X, Meadows E, McAnally J, Pomajzl C, Shelton JM, Richardson JA, Karsenty G, Olson EN, Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell. 2004 Nov 12;119(4):555-66
1*	J:320688 Wada S, Ideno H, Shimada A, Kamiunten T, Nakamura Y, Nakashima K, Kimura H, Shinkai Y, Tachibana M, Nifuji A, H3K9MTase G9a is essential for the differentiation and growth of tenocytes in vitro. Histochem Cell Biol. 2015 Jul;144(1):13-20
1	J:48562 Wai AW, Ng LJ, Watanabe H, Yamada Y, Tam PP, Cheah KS, Disrupted expression of matrix genes in the growth plate of the mouse cartilage matrix deficiency (cmd) mutant. Dev Genet. 1998;22(4):349-58
1	J:316121 Wang JR, Wang CJ, Xu CY, Wu XK, Hong D, Shi W, Gong Y, Chen HX, Long F, Wu XM, Signaling Cascades Governing Cdc42-Mediated Chondrogenic Differentiation and Mensenchymal Condensation. Genetics. 2016 Mar;202(3):1055-69
1	J:132462 Wang K, Yamamoto H, Chin JR, Werb Z, Vu TH, Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment. J Biol Chem. 2004 Dec 17;279(51):53848-56
1	J:223511 Wei J, Shimazu J, Makinistoglu MP, Maurizi A, Kajimura D, Zong H, Takarada T, Lezaki T, Pessin JE, Hinoi E, Karsenty G, Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation. Cell. 2015 Jun 18;161(7):1576-91
1	J:148141 Wu Q, Chen D, Zuscik MJ, O'Keefe RJ, Rosier RN, Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin. J Bone Miner Res. 2008 Apr;23(4):552-63
1*	J:307192 Yadav PS, Feng S, Cong Q, Kim H, Liu Y, Yang Y, Stat3 loss in mesenchymal progenitors causes Job syndrome-like skeletal defects by reducing Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):e2020100118
1*	J:308829 Yamaguchi H, Meyer MD, He L, Senavirathna L, Pan S, Komatsu Y, The molecular complex of ciliary and golgin protein is crucial for skull development. Development. 2021 Jul 1;148(13):dev199559
1*	J:80668 Yoshida CA, Furuichi T, Fujita T, Fukuyama R, Kanatani N, Kobayashi S, Satake M, Takada K, Komori T, Core-binding factor beta interacts with Runx2 and is required for skeletal development. Nat Genet. 2002 Dec;32(4):633-8
1	J:89327 Yoshida CA, Yamamoto H, Fujita T, Furuichi T, Ito K, Inoue K, Yamana K, Zanma A, Takada K, Ito Y, Komori T, Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev. 2004 Apr 15;18(8):952-63
1*	J:28954 Yoshioka H, Iyama K, Inoguchi K, Khaleduzzaman M, Ninomiya Y, Ramirez F, Developmental pattern of expression of the mouse alpha 1 (XI) collagen gene (Col11a1). Dev Dyn. 1995 Sep;204(1):41-7
1	J:218833 Zhao H, Zhou W, Yao Z, Wan Y, Cao J, Zhang L, Zhao J, Li H, Zhou R, Li B, Wei G, Zhang Z, French CA, Dekker JD, Yang Y, Fisher SE, Tucker HO, Guo X, Foxp1/2/4 regulate endochondral ossification as a suppresser complex. Dev Biol. 2015 Feb 15;398(2):242-54
1	J:286157 Zheng C, Lin X, Xu X, Wang C, Zhou J, Gao B, Fan J, Lu W, Hu Y, Jie Q, Luo Z, Yang L, Suppressing UPR-dependent overactivation of FGFR3 signaling ameliorates SLC26A2-deficient chondrodysplasias. EBioMedicine. 2019 Feb;40:695-709